Sorry for necro-bumping the thread, but I opened an account to say "thanks" to this info!crisisacting wrote: ↑19 Feb 2025, 21:21 Only NVMe 1 & 2 slots (off the ASMedia ASM2806) should be avoided; the rest should all be from the integrated PCH & allow for VT-d to remain enabled.
I was very surprised to see higher load + temperature after adding 2 more NVME's to my F8-SSD. My previous couple was sitting on slots 1&2, the new ones were installed on 5&6. VT-d was disabled. The whole thing was too confusing until I saw millions of interrupts coming from ACPI, hammering cpu0.
Now I moved the older duo from 1&2 -> 3&4, peace again. Also I enabled VT-d, as a cherry on top!

