Just installed a pair of P3 Crucial Nvme 500Gb drives in my F2-424.
No issues as far as I can see. Short test in Bios passed.
Nvme on F2-424 = Crucial P3 500GB
Nvme on F2-424 = Crucial P3 500GB
F5-221 TOS7.0.0777 - 4x4TB (Ironwolf) Traid
F2-424 TOS7.0.0777 - 2x500GB nvme (P3) Traid, 2x6TB HDD (HGST) Traid
F2-221 TOS7.0.0777 - 1x3TB Ext4, 1x4TB Btrfs
F2-425+ TOS7.0.0777 - 2x500GB nvme (P3) Traid, 2x6TB HDD (EXOS) Traid
F2-424 TOS7.0.0777 - 2x500GB nvme (P3) Traid, 2x6TB HDD (HGST) Traid
F2-221 TOS7.0.0777 - 1x3TB Ext4, 1x4TB Btrfs
F2-425+ TOS7.0.0777 - 2x500GB nvme (P3) Traid, 2x6TB HDD (EXOS) Traid
Re: Nvme on F2-424 = Crucial P3 500GB
Some quick testing: NVMe drives only, empty caddies installed to replicate airflow conditions, transfer >6000 files via smb mixture of large(ish) and small. [ Includes TOS install & updates, Windows isos, apps]
speeds better than 100MB/s on a single gigabit link. Fan speed set to medium (for safety).
Temps hardly twitched:

Drives are fitted with 2mm copper heatsinks (with thermal layer).
speeds better than 100MB/s on a single gigabit link. Fan speed set to medium (for safety).
Temps hardly twitched:

Drives are fitted with 2mm copper heatsinks (with thermal layer).
F5-221 TOS7.0.0777 - 4x4TB (Ironwolf) Traid
F2-424 TOS7.0.0777 - 2x500GB nvme (P3) Traid, 2x6TB HDD (HGST) Traid
F2-221 TOS7.0.0777 - 1x3TB Ext4, 1x4TB Btrfs
F2-425+ TOS7.0.0777 - 2x500GB nvme (P3) Traid, 2x6TB HDD (EXOS) Traid
F2-424 TOS7.0.0777 - 2x500GB nvme (P3) Traid, 2x6TB HDD (HGST) Traid
F2-221 TOS7.0.0777 - 1x3TB Ext4, 1x4TB Btrfs
F2-425+ TOS7.0.0777 - 2x500GB nvme (P3) Traid, 2x6TB HDD (EXOS) Traid
